BSC2346 Module 04 Case Study
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• Question 1 Jordan is now 19-years old. As an infant, Jordan reached many gross motor skill milestones, such as holding his head up, rolling over, sitting, and standing, at normal times. However, he was considered a “late walker” because he took his first steps at 17 months. By 2 years old, his parents noticed a hyperlordotic posture while he was standing. A Gower’s sign and Trendelenberg gait were noted by age four. Throughout his childhood, he suffered progressive muscle weakness, especially in the proximal musculature of the arms, pelvis, and legs. He required orthotic braces to assist his walking and was confined to wheelchair ambulation by age 13.
At 16, he was hospitalized with bronchitis requiring antibiotic treatment, but recovered. Jordan has a history of progressive muscle weakness, but no history of muscle pain or spasm, chest pain, or irregular heartbeat. The only medications that he normally takes are calcium and fluoride supplements. Jordan has three siblings. His older and younger sisters have never had any major medical issues. Jordan’s older brother is also to a wheelchair with problems similar to Jordan’s. No other immediate or distant family members have musculoskeletal issues.
Jordan’s history aligns most closely with which diagnosis?
• Question 2 Jordan had a biopsy of the left gastrocnemius muscle when he was 5 years old. Based on your answer for his diagnosis, describe the microscopic pathological changes that the pathologist would have noted in her report.
• Question 3 Explain, in your own words, why Jordan’s brother appears to have the same disease and why his sisters are unaffected.
• Question 4 Jordan’s calves appear enlarged. Which of the following statements explains this phenomenon?
• Question 5 Jordan displayed Gower’s sign at a young age. Which of the following statements explains why this this true?
• Question 6 Weakness in his erector spinae muscles forces Jordan to assume which exaggerated position when standing?
• Question 7 In your own words, please explain why Jordan must take calcium supplements for the rest of his life. (Hint: Think about your prior material and Wolff’s law.)
• Question 8 Jordan is prone to respiratory infections, in part because of the weakness of which muscles?
• Question 9 Genetic testing would reveal that Jordan has a y-linked disorder.
• Question 10 In your own words, briefly describe the role of dystrophin within the motor unit.
• Question 11 Colette has been experiencing some muscle pain and soreness after workouts this last week. She decides to research how muscles work because she wants to find ways to help alleviate her pain. She is hoping to find out the names of the muscles that are aching and find ways to stretch and strengthen them. Answer the following questions to help her find the answers she is looking for.
Colette has been sore “all over,” but her primary area of concern is the posterior right thigh. Which of the following muscles could be causing the soreness in this region?
• Question 12 Colette has played softball for over 20 years and has been told in the past that she may have a rotator cuff injury. Which of the following rotator cuff muscles is on the anterior aspect of the scapula?
• Question 13 Colette is trying to understand what causes her occasional calf muscle cramps. Which of the following statements is true regarding cramps?
• Question 14 According to the sliding filament theory, myosin filaments slide past actin filaments during contraction of a muscle because the myosin heads bind to the sarcolemma.
• Question 15 Which of the following statements is true regarding muscle contraction?
• Question 16 Colette is having trouble understanding the role of fascia within the musculoskeletal system. Explain, in your own words, how fascia is related to the muscles of the human body.
• Question 17 Colette is finding that studies about the benefits of stretching have mixed results. However, stretching can improve flexibility, which is a priority for her. Which of the following statements is true?
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• Question 18 In your own words, describe how acetylcholine, calcium, and ATP are involved in the process of muscle contraction.
• Question 19 While Colette is researching weight lifting techniques, she finds contradictory information about the “best” way to build muscle. Which of the following statements is true of skeletal muscle?
• Question 20 Muscle relaxation occurs when acetylcholine is cleaved from its receptors, calcium is pulled back inot the sarcoplasmic reticulum, the myosin is released from its binding site, and the muscle fiber returns to its resting length.
BSC2346 Module 04 Case Study
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